PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Hydroxy-PEG5-C1-Boc
0 ImagesSynonyms: Hydroxy-PEG5-t-butyl acetate
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N-(4-Carboxycyclohexylmethyl)maleimide
0 ImagesCat. No.: HY-42359CAS No.: 64987-82-2
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DBCO-PEG4-Desthiobiotin
0 ImagesCat. No.: HY-140301CAS No.: 2032788-37-5
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HS-PEG5-CH2CH2NH2 hydrochloride
0 ImagesSynonyms: Thiol-PEG5-amine hydrochloride
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Phenol-amido-C1-PEG3-N3
0 ImagesSynonyms: PROTAC Linker 21Phenol-amido-C1-PEG3-N3 (PROTAC Linker 21) is an PEG-based PROTAC linker can be used in the synthesis of PROTACs. Phenol-amido-C1-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-PEG10-NHS ester
0 ImagesCat. No.: HY-130824CAS No.: 2221949-02-4Bis-PEG10-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG10-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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4-(Benzyloxy)butan-1-ol
0 ImagesCat. No.: HY-W092164CAS No.: 4541-14-4
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2,5-Dioxopyrrolidin-1-yl 3-((tert-butoxycarbonyl)amino)propanoate
0 ImagesSynonyms: Boc-Beta-Ala-OSu
![2-Boc-2,6-Diazaspiro[3.3]heptane hemioxalate](https://file.medchemexpress.com/product_pic/hy-30842.gif "Click to View 2-Boc-2,6-Diazaspiro[3.3]heptane hemioxalate Product Detail")
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6-Bromohexan-1-amine hydrobromide
0 ImagesSynonyms: 6-Bromohexylamine Hydrobromide
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tert-Butyl (6-hydroxyhexyl)carbamate
0 ImagesCat. No.: HY-W014096CAS No.: 75937-12-1
![tert-Butyl (6-hydroxyspiro[3.3]heptan-2-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-34928.gif "Click to View tert-Butyl (6-hydroxyspiro[3.3]heptan-2-yl)carbamate Product Detail")
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5-Iodopent-1-yne
0 ImagesCat. No.: HY-W035972CAS No.: 2468-55-5Synonyms: 5-Iodo-1-pentyne
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tert-Butyl 3-hydroxypropanoate
0 ImagesCat. No.: HY-W047702CAS No.: 59854-11-4
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Pent-4-yn-1-amine hydrochloride
0 ImagesCat. No.: HY-W045431CAS No.: 173987-24-1
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Boc-C4-ethyne
0 ImagesCat. No.: HY-W247244CAS No.: 1203588-17-3
